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Pseudo-Peptides in Drug Development

Category: eBooks


Pseudo-Peptides in Drug Development
Pseudo-Peptides in Drug Development By
2004 | 252 Pages | ISBN: 3527306331 | PDF | 4 MB
Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. To overcome this problem, stable and at the same time biologically active pseudo-peptides have been developed. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific and non-toxic pharmaceuticals. This is the first work devoted to the topic and draws together knowledge gained on different types of peptidomimetics and other pseudo-peptides with drug properties. As such, it includes peptoids, beta-peptides, polyamide DNA binders as well as peptide nucleic acids. The expert authors and editor discuss chemical properties and stability, biological activity and reactivity, as well as practical aspects of synthesis, making this a prime resource for drug developers and bioorganic chemists working with these compounds.Content: Chapter 1 Versatile Oligo(N?Substituted) Glycines: The Many Roles of Peptoids in Drug Discovery (pages 1-31): James A. Patch, Kent Kirshenbaum, Shannon L. Seurynck, Ronald N. Zuckermann and Annelise E. BarronChapter 2 ??Peptides, ??Peptides and Isosteric Backbones: New Scaffolds with Controlled Shapes for Mimicking Protein Secondary Structure Elements (pages 33-120): Gilles GuichardChapter 3 Regulation of Gene Expression with Pyrrole?Imidazole Polyamides (pages 121-152): Peter B. Dervan, Eric J. Fechter, Benjamin S. Edelson and Joel M. GottesfeldChapter 4 Peptide Nucleic Acid (PNA): A Pseudo?peptide with DNA?like Properties (pages 153-191): Peter E. Nielsen, Uffe Koppelhus and Frederik BeckChapter 5 ??Helical Peptide Nucleic Acids (?PNAs) (pages 193-221): Philip Garner, Subhakar Dey and Yumei HuangChapter 6 DNA and RNA?cleaving Pseudo?peptides (pages 223-240): Alessandro Scarso and Paolo Scrimin



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