Molsoft ICM-Pro 3.9-5 (x64)
Date: 9 October 2026 | Posted by: voska89
Free Download Molsoft ICM-Pro 3.9-5 (x64) | 1.7 GB
Molsoft ICM-Pro is a desktop application for protein structure analysis, molecular modeling, and molecular docking, designed for researchers working in biology, chemistry, structural biology, and drug discovery. It combines molecular visualization, computational analysis, and interactive ligand design tools within a single environment.
The software provides access to protein sequence and structural databases, enabling users to examine molecular structures, analyze sequence alignments, investigate binding pockets, and study interactions between proteins and small molecules. Additional capabilities include electrostatic surface calculations, mutation modeling, binding-site prediction, and protein-protein interaction analysis.
ICM-Pro also supports interactive ligand modification within receptor binding sites. Researchers can adjust chemical structures, evaluate changes in ligand binding energy and scoring, and perform docking and energy minimization to investigate potential molecular interactions.
Software Overview
Molsoft ICM-Pro provides tools for studying the structural and physical properties of biological molecules. Its protein analysis capabilities include examining three-dimensional structures, comparing molecular conformations, measuring distances and angles, and evaluating contacts, surface areas, and hydrogen bonds.The application connects directly to the Protein Data Bank (PDB), allowing researchers to retrieve structural data for further investigation. Visualization and analysis tools help users interpret molecular geometry, electrostatic properties, ligand-binding pockets, and crystallographic information.
For molecular design and drug discovery workflows, ICM-Pro includes pocket detection and interactive ligand editing. Researchers can investigate potential binding sites, modify chemical groups within a receptor pocket, and assess how structural changes affect docking scores and calculated binding energies.
Crystallographic analysis tools provide additional insight into the experimental data associated with protein structures. Users can examine biological assemblies, investigate possible crystal-packing contacts, and visualize electron density to assess the structural evidence supporting ligand placement in an active site.
Key Features
- Protein structure visualization and structural analysis.
- Direct access to the Protein Data Bank (PDB).
- Sequence analysis and alignment inspection.
- Structural superimposition for comparing multiple molecular structures.
- Ramachandran plot generation for evaluating protein backbone geometry.
- Distance, angle, contact area, and surface area calculations.
- Hydrogen-bond analysis and electrostatic surface visualization.
- Ligand-binding pocket identification using ICM Pocket Finder.
- Binding-pocket property calculations and drug-likeness scoring.
- Prediction of ligand-binding sites in protein, DNA, and RNA structures.
- Protein-protein interaction site prediction.
- Small-molecule docking and protein-protein docking.
- Interactive ligand editing within receptor binding pockets.
- Evaluation of ligand binding energy and docking scores following chemical modifications.
- Ligand redocking and energy minimization.
- Crystallographic analysis of biological assemblies, crystal contacts, and electron density.
Why Choose Molsoft ICM-Pro
Molsoft ICM-Pro brings structural inspection, molecular modeling, docking, and ligand design together in one desktop environment. This makes it useful for researchers who need to move between examining experimental structures and evaluating potential molecular interactions.Its combination of binding-pocket analysis, interactive chemical editing, and crystallographic visualization supports investigations ranging from protein structure characterization to computational drug discovery. The ability to examine molecular geometry and evaluate ligand modifications can help researchers compare candidate structures during their modeling workflows.
System Requirements
- OS:All windows is supported
- Space:1 GB of disk space and
- Memory:2Gb or more of RAM4Gb is a good default.
- GPU:GeForce models are good if you do not plan to use hardware stereo.
Home Page
https://www.molsoft.com
Product Information
- Software Name: Molsoft ICM-Pro
- Version: 3.9-5
- Architecture: x64
- Languages: English
- License type: Full Version
- File Size: 1.7 GB
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